Digaagga Collagen nooca ii ee aan la daboolin ee Caafimaadka Wadajirka ah
| Magaca alaabta | Digaagga Collagen nooca ii ee aan la daboolin ee Caafimaadka Wadajirka ah |
| Asal ahaan walxaha | sternum digaag |
| Muuqashada | Caddaan ilaa yar budo huruud ah |
| Habka wax soo saarka | Habka biyo-dhisidda heerkulka hooseeya |
| Nooca aan la daboolin ee collagen | ＞10% |
| Wadarta nuxurka borotiinka | 60% (Qaabka Kjeldahl) |
| Quudinta qoyaanka | ≤10% (105° ilaa 4 saacadood) |
| Cufnaanta weyn | 0.5g/ml sida cufnaanta bulk |
| Solubility | Ku milmayn wanaagsan biyaha |
| Codsiga | Si loo soo saaro kaabayaasha daryeelka wadajirka ah |
| Nolosha shelf | 2 sano laga bilaabo taariikhda wax soo saarka |
| Baakad | Xirmooyinka gudaha: Bacaha PE-da ee xidhan |
| Baakadaha dibadda: 25kg/Drum |
Nooca II kolajka aan la daboolin waa nooca II ee kolajka laga soo saaro sternum digaaga iyada oo si fiican loo xakameynayo loona horumariyay habka wax soo saarka si borotiinka kolajku uu yahay mid aan la daboolin.Erayga "Undenatured" waxaa loola jeedaa qaab dhismeedka molecular ee nooca ii collagen ku hadhay asalka Triple Helix Structure sida habka uu yahay in jidhka xayawaanka xitaa ka dib markii la soo saaray oo xasiloon sternum digaagga.
Nooca kolajka digaaga ee aan la daboolin ee II waa kolajka firfircoon kaas oo ku sii jira qaab dhismeedka molecule-kiisii asalka ahaa halka kolajka denatured uu shaqadiisa ku waayay habka biyo-saarista.Unugyada firfircoonida ee kolajka ayaa muhiim u ah kolajka si uu ugu shaqeeyo jawaabta difaaca ee nooc ka mid ah caabuqa cudurrada wadajirka ah.
Nooca II kolajka laftiisa ayaa ah qaabka ugu muhiimsan ee kolajka ee ku jira kilyaha wadajirka ah.Glycosaminoglycan ee nooca ii collagen waa qayb muhiim ah oo ka mid ah lafaha iyo carjawda articular ee daloolka wadajirka ah ee synovial.Waxay ka caawisaa kor u hagaajinta carjawda iyo saliidda wadajirka ah.
| PARAAMETER | QAABKA |
| Muuqashada | Caddaan ilaa budo cad ah |
| Isku geynta Borootiiniinta | 50%-70% (Qaabka Kjeldahl) |
| Nooca II ee Collagen aan la daboolin | ≥10.0% (Habka Elisa) |
| Mucopolysaccharide | Wax ka yar 10% |
| pH | 5.5-7.5 (EP 2.2.3) |
| Hadhaaga dabka | ≤10% (EP 2.4.14) |
| Luminta qalajinta | ≤10.0% (EP2.2.32) |
| Birta culus | 20 PPM (EP2.4.8) |
| Hogaamin | 1.0mg/kg( EP2.4.8) |
| Meerkuri | 0.1mg/kg( EP2.4.8) |
| Cadmium | 1.0mg/kg( EP2.4.8) |
| Arsenic | 0.1mg/kg( EP2.4.8) |
| Wadarta tirada bakteeriyada | 1000cfu/g(EP.2.2.13) |
| Khamiirka & Caaryada | 100cfu/g(EP.2.2.12) |
| E.Coli | Maqnaanshaha/g (EP.2.2.13) |
| Salmonella | Maqnaanshaha/25g (EP.2.2.13) |
| Staphylococcus aureus | Maqnaanshaha/g (EP.2.2.13) |
1. Waxyaabaha ugu sarreeya ee kolajka aan la daboolin ee nooca ii: Nooca kolajka aan la daboolin ee ii waxaa soo saaray hab wax soo saar gaar ah, kaas oo ilaaliya dhaqdhaqaaqa kolajka isla markaana nadiifiya walxaha si ay ugu jiraan waxyaabo badan oo kolajka aan la daboolin.Soosaarayaasha kale waxay ka koobnaan karaan ilaa 3%, 9% collagen nooca ii kaas oo aan bixin karno ilaa 25% nooca kolajka aan la daboolin ee ii.
2. Cufnaanta Bulk Sare oo leh socodka wanaagsan: Nooca kolajkayaga aan la daboolin ee II waa cufnaanta bulk sare ee agagaarka 0.5g/ml iyo sidoo kale qulqulka wanaagsan, taas oo ka dhigaysa mid ku habboon in la soo saaro kiniinno ama kaabsal.
3. Tayada GMP: Budada kolajka ee aan bixinay waxaa lagu soo saaraa xarunta GMP iyadoo loo eegayo shuruudaha GMP.Waxa lagu tijaabiyaa shaybaadhkayaga ka hor inta aanaan alaabta kuu sii deyn.
1. Caawintu waxay yaraynaysaa bararka ay keento jawaab celinta difaaca ee ka hortagga nooca II kolajka endogenous, kaas oo loo yaqaan dulqaad la'aanta autoimmune.
Nooca Collagen-ka aan la daboolin ee II wuxuu hayaa qaab-dhismeedka helix-ga saddex-geesoodka ah ee dabiiciga ah kaasoo xajiya cunsur antigenic, kaas oo ka dhigaya kolajku inuu yeesho awood isku-xidhka antigen-antibody.Rumatoid arthritis-ku wuxuu dhacaa marka jirku soo saaro unugyada difaaca jirka ee ka hortagga autoantigens.Cilmi-baaristii ugu dambeysay waxay muujineysaa in qaadashada qaddar yar oo firfircoon nooca II kolajka ay u horseedi doonto jirka inuu tixgeliyo nooca II borotiinka inuu yahay is-antigen, kaas oo ka hortagi doona jiilka autoantibody.Sidan, waxay hoos u dhigi doontaa cilladaha rheumatoid arthritis-ka.
2. Nooca Collagen-ka aan la daboolin ee ii wuxuu ka kooban yahay glycosaminoglycans badan.Isku darka glycosaminoglycans iyo borotiinnada asaasiga ah waxay gacan ka geystaan kor u qaadida jiilka proteoglycans ee carjawooyinka.Sidan oo kale, nooca collagen-ka firfircoon ee II wuxuu dib u soo celinayaa dheelitirka dib-u-dhiska unugyada carjawda iyo sidoo kale hagaajinta carjawda dhaawacan.
3. Nooca Collagen Undenatured II waxa uu ka kooban yahay hydroxyproline ka badan nooca caadiga ah ee collagen, kaas oo si aad ah u anfacaya ku dhejinta calcium, fosfooraska iyo qaybaha kale ee macdanta si ay u noqdaan lafo.Sidaa darteed, waxaa si ballaaran loo isticmaalaa sida qayb ka mid ah supplements caafimaadka wadajir ah.
Daraasad cilmiyeedku waxay caddaynaysaa in AC-II ay bixiso faa'iidooyinka caafimaadka wadajirka ah.Daraasada bukaan-socodka ee xayawaanku waxay caddaynaysaa in faa'iidooyinka AC-II lagu xaqiijiyay tijaabooyinka osteoarthritis-ka-xanuunnada, dhaawacyada-ka-soo-baxa iyo cayilka-cunida-xanuunka ee jiirka.
Tijaabada osteoarthritis-ka ee ka dib, dhaawaca wadajirka ah wuxuu keenay lumitaanka carjawda (matrix iyo chondrocytes) iyo bararka degaanka ee daran ee wadajirka jilibka.Ka dib qaadashada qaddar-hooseeya Active Collagen II, faa'iidooyinka soo socda ayaa si cad loo caddeeyey:
1. Kahortagga Naafaynta Carjawda iyo Saliidda
AC-II waxay ilaalin kartaa carjawda waxayna yareyn kartaa isbeddellada qallafsan (caadiyan gobolka chondroitin, baararka buluuga ah ee dhinaca bidix ee jaantuska hoose), waxay kicisaa isku-darka proteoglycan ee chondrocytes waxayna kor u qaadaa sifeynta wadajirka ah (boqolkiiba chondrocytes firfircoon waxay kordhisaa, sida lagu muujiyay buluugga buluuga ah. histogram ka dhanka midig ee jaantuska hoose).
Jaantuska No.1: Nooca Collagen Chicken Undenatured II Waxay ka hortagtaa nabaad-guurka carjawda waxayna kor u qaadaa isku-dhafka maaddooyinka saliidda.
2. Iska yaree bararka
Nooca kolajka digaaga ee aan la daboolin ee II wuxuu kor u qaadaa saamaynta anti-bararka ee kala-goysyada jilibka (waxay yaraynaysaa muujinta calaamadaha caabuqa gudaha xuubka synovial, Eeg histogram buluug ah jaantuska hoose).
Jaantuska No.2: Nooca kolajka digaaga ee aan la daboolin ee ii wuxuu yareeyaa bararka OA.
3. Kahortagga OA (Osteoarthritis)
Tijaabada osteoarthritis ee buuran iyo naxdinta leh, lumitaanka kilyaha wadajirka ah ee jilibka (matrix iyo chondrocytes) iyo jawaabta bararka maxalliga ah ayaa si ku-meel-gaar ah loo kiciyay.Qiyaas yar
Nooca digaaga collagen ee aan la daboolin ee dheeriga ah wuxuu ka hortagi karaa lafo-xanuunka dhinacyada soo socda:
Tijaabooyin lagu sameeyay jiirarka ku cayilan cuntooyinka dufanku ku badan yihiin ayaa muujiyay ilaalinta carjawda, hoos u dhigida isbeddellada xumeeyay (caadi ahaan aagga carjawda, histogram buluug ah oo ku yaal dhinaca bidix ee jaantuska hoose), iyo kor u qaadista saliidda wadajirka ah iyada oo kicinaysa isku-darka proteoglycan ee chondrocytes ( Boqolkiiba chondrocytes firfircooni waxay kordhisaa, histogaraamka buluuga ah ee dhinaca midig ee jaantuska hoose).
Jaantuska No.3: Digaagga aan la daboolin ee Collagen nooca ii wuxuu ka hortagayaa hoos u dhaca carjawda wuxuuna kor u qaadaa isku-darka matrixka saliidda leh ee osteoarthritis ee uu keeno buurnaanta.
4. bioavailability sare
Daraasadu waxay muujinaysaa in 1 saac ka dib qaadashada nooca Undenatured ii hydroxyproline ee serum mouse ay gaadho heer aad u sarreeya, taas oo caddaynaysa in nooca digaaga Undenatured ii uu leeyahay bioavailability sare.
Jaantuska 4: Digaagga aan la daboolin ee Collagen nooca ii waxa u nuugi kara si hufan.
Caadi ahaan, nooca kolajka aan la daboolin ee II ayaa loo isticmaalaa in lagu soo saaro kaabsal adag oo ka kooban nooca Undenatured ii collagen.Waxaa laga yaabaa in lala isticmaalo maaddooyinka kale ee caafimaadka wadajirka ah sida chondroitin sulfate, glucosamine iyo hyaluronic acid.
Foomka qiyaasta qiyaasta ugu caansan ee dhammays tiran ee nooca kolajka digaaga ee aan la daboolin ee ii waa lafaha iyo kaabsoosha caafimaadka wadajirka ah.Nooca kolajka digaaga ee aan la daboolin ayaa leh socodka wanaagsan waxaana si fudud loogu buuxin karaa kaabsal.
Ereyga ganacsiga: MOQ, muunadda iyo qiimaha
Xiritaanka: Xirmooyinkayadu waa 25KG/Drum dalabaadka ganacsi ee waaweyn.Dalabka tirada yar, waxaan ku sameyn karnaa baakad sida 1KG,5KG, ama 10KG, 15KG ee bacaha birta aluminiumka ah.
Siyaasadda Tusaalaha: Waxaan ku bixin karnaa ilaa 30 garaam oo bilaash ah.Caadi ahaan muunada waxaan u dirnaa DHL, haddii aad leedahay akoon DHL, fadlan si naxariis leh nala wadaag.
Qiimaha: Waxaan soo qaadan doonaa qiimaha ku salaysan caddaymaha iyo tirada kala duwan.
Adeegga Gaarka ah: Waxaan u heellannahay kooxda iibka si ay wax uga qabtaan weydiimahaaga.Waxaan ballan qaadaynaa inaad hubiso inaad jawaab ku heli doonto 24 saacadood gudahood tan iyo markii aad soo dirtay su'aalo.
